Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy
Identifieur interne : 000744 ( Main/Exploration ); précédent : 000743; suivant : 000745Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy
Auteurs : P. Rocheteau [France] ; L. Chatre [France] ; D. Briand [France] ; M. Mebarki [France] ; G. Jouvion [France] ; J. Bardon [France] ; C. Crochemore [France] ; P. Serrani [France] ; P. P. Lecci [France] ; M. Latil [France] ; B. Matot [France] ; P. G. Carlier [France] ; N. Latronico [Italie] ; C. Huchet [France] ; A. Lafoux [France] ; T. Sharshar [France] ; M. Ricchetti [France] ; F. Chrétien [France]Source :
- Nature Communications [ 2041-1723 ] ; 2015.
Abstract
Sepsis, or systemic inflammatory response syndrome, is the major cause of critical illness resulting in admission to intensive care units. Sepsis is caused by severe infection and is associated with mortality in 60% of cases. Morbidity due to sepsis is complicated by neuromyopathy, and patients face long-term disability due to muscle weakness, energetic dysfunction, proteolysis and muscle wasting. These processes are triggered by pro-inflammatory cytokines and metabolic imbalances and are aggravated by malnutrition and drugs. Skeletal muscle regeneration depends on stem (satellite) cells. Herein we show that mitochondrial and metabolic alterations underlie the sepsis-induced long-term impairment of satellite cells and lead to inefficient muscle regeneration. Engrafting mesenchymal stem cells improves the septic status by decreasing cytokine levels, restoring mitochondrial and metabolic function in satellite cells, and improving muscle strength. These findings indicate that sepsis affects quiescent muscle stem cells and that mesenchymal stem cells might act as a preventive therapeutic approach for sepsis-related morbidity.
Url:
DOI: 10.1038/ncomms10145
PubMed: 26666572
PubMed Central: 4682118
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000014
- to stream Pmc, to step Curation: 000014
- to stream Pmc, to step Checkpoint: 000005
- to stream PubMed, to step Corpus: 000026
- to stream PubMed, to step Curation: 000026
- to stream PubMed, to step Checkpoint: 000035
- to stream Ncbi, to step Merge: 000218
- to stream Ncbi, to step Curation: 000210
- to stream Ncbi, to step Checkpoint: 000210
- to stream Main, to step Merge: 000733
- to stream Main, to step Curation: 000744
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy</title><author><name sortKey="Rocheteau, P" sort="Rocheteau, P" uniqKey="Rocheteau P" first="P." last="Rocheteau">P. Rocheteau</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chatre, L" sort="Chatre, L" uniqKey="Chatre L" first="L." last="Chatre">L. Chatre</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Developmental and Stem Cell Biology, Institut Pasteur, Stem Cells and Development</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Team Stability of Nuclear and Mitochondrial DNA, CNRS UMR 3525</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Briand, D" sort="Briand, D" uniqKey="Briand D" first="D." last="Briand">D. Briand</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mebarki, M" sort="Mebarki, M" uniqKey="Mebarki M" first="M." last="Mebarki">M. Mebarki</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jouvion, G" sort="Jouvion, G" uniqKey="Jouvion G" first="G." last="Jouvion">G. Jouvion</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bardon, J" sort="Bardon, J" uniqKey="Bardon J" first="J." last="Bardon">J. Bardon</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Crochemore, C" sort="Crochemore, C" uniqKey="Crochemore C" first="C." last="Crochemore">C. Crochemore</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Developmental and Stem Cell Biology, Institut Pasteur, Stem Cells and Development</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Team Stability of Nuclear and Mitochondrial DNA, CNRS UMR 3525</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Serrani, P" sort="Serrani, P" uniqKey="Serrani P" first="P." last="Serrani">P. Serrani</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lecci, P P" sort="Lecci, P P" uniqKey="Lecci P" first="P. P." last="Lecci">P. P. Lecci</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Latil, M" sort="Latil, M" uniqKey="Latil M" first="M." last="Latil">M. Latil</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Matot, B" sort="Matot, B" uniqKey="Matot B" first="B." last="Matot">B. Matot</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>NMR Laboratory, Institute of Myology</institution>, Paris 75013,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>CEA, I2BM, MIRCen, NMR Laboratory</institution>, Paris 75013,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Carlier, P G" sort="Carlier, P G" uniqKey="Carlier P" first="P. G." last="Carlier">P. G. Carlier</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>NMR Laboratory, Institute of Myology</institution>, Paris 75013,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>CEA, I2BM, MIRCen, NMR Laboratory</institution>, Paris 75013,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Latronico, N" sort="Latronico, N" uniqKey="Latronico N" first="N." last="Latronico">N. Latronico</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Anesthesia and Reanimation Department, Department of Surgery, University of Brescia</institution>, Brescia 25121,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huchet, C" sort="Huchet, C" uniqKey="Huchet C" first="C." last="Huchet">C. Huchet</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>INSERM UMR1087/ CNRS UMR6291, Institut du Thorax, Therassay, Université de Nantes, Faculté des Sciences et des Techniques</institution>, F44322 Nantes 44000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lafoux, A" sort="Lafoux, A" uniqKey="Lafoux A" first="A." last="Lafoux">A. Lafoux</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>INSERM UMR1087/ CNRS UMR6291, Institut du Thorax, Therassay, Université de Nantes, Faculté des Sciences et des Techniques</institution>, F44322 Nantes 44000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sharshar, T" sort="Sharshar, T" uniqKey="Sharshar T" first="T." last="Sharshar">T. Sharshar</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Service de réanimation médico-chirurgicale adulte, Hôpital Raymond Poincaré</institution>, Garches 92380,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Université Versailles Saint Quentin</institution>, Versailles 78000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>TRIGGERSEP, F-CRIN Network</institution>, Versailles 78000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ricchetti, M" sort="Ricchetti, M" uniqKey="Ricchetti M" first="M." last="Ricchetti">M. Ricchetti</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Developmental and Stem Cell Biology, Institut Pasteur, Stem Cells and Development</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Team Stability of Nuclear and Mitochondrial DNA, CNRS UMR 3525</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chretien, F" sort="Chretien, F" uniqKey="Chretien F" first="F." last="Chrétien">F. Chrétien</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>TRIGGERSEP, F-CRIN Network</institution>, Versailles 78000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Laboratoire de Neuropathologie, Centre Hospitalier Sainte Anne</institution>, Paris 75014,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a12"><institution>Paris Descartes University, Sorbonne Paris Cité</institution>, Paris 75006,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26666572</idno><idno type="pmc">4682118</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682118</idno><idno type="RBID">PMC:4682118</idno><idno type="doi">10.1038/ncomms10145</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000014</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000014</idno><idno type="wicri:Area/Pmc/Curation">000014</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000014</idno><idno type="wicri:Area/Pmc/Checkpoint">000005</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000005</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000026</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000026</idno><idno type="wicri:Area/PubMed/Curation">000026</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000026</idno><idno type="wicri:Area/PubMed/Checkpoint">000035</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000035</idno><idno type="wicri:Area/Ncbi/Merge">000218</idno><idno type="wicri:Area/Ncbi/Curation">000210</idno><idno type="wicri:Area/Ncbi/Checkpoint">000210</idno><idno type="wicri:Area/Main/Merge">000733</idno><idno type="wicri:Area/Main/Curation">000744</idno><idno type="wicri:Area/Main/Exploration">000744</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy</title><author><name sortKey="Rocheteau, P" sort="Rocheteau, P" uniqKey="Rocheteau P" first="P." last="Rocheteau">P. Rocheteau</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chatre, L" sort="Chatre, L" uniqKey="Chatre L" first="L." last="Chatre">L. Chatre</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Developmental and Stem Cell Biology, Institut Pasteur, Stem Cells and Development</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Team Stability of Nuclear and Mitochondrial DNA, CNRS UMR 3525</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Briand, D" sort="Briand, D" uniqKey="Briand D" first="D." last="Briand">D. Briand</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mebarki, M" sort="Mebarki, M" uniqKey="Mebarki M" first="M." last="Mebarki">M. Mebarki</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jouvion, G" sort="Jouvion, G" uniqKey="Jouvion G" first="G." last="Jouvion">G. Jouvion</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bardon, J" sort="Bardon, J" uniqKey="Bardon J" first="J." last="Bardon">J. Bardon</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Crochemore, C" sort="Crochemore, C" uniqKey="Crochemore C" first="C." last="Crochemore">C. Crochemore</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Developmental and Stem Cell Biology, Institut Pasteur, Stem Cells and Development</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Team Stability of Nuclear and Mitochondrial DNA, CNRS UMR 3525</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Serrani, P" sort="Serrani, P" uniqKey="Serrani P" first="P." last="Serrani">P. Serrani</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lecci, P P" sort="Lecci, P P" uniqKey="Lecci P" first="P. P." last="Lecci">P. P. Lecci</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Latil, M" sort="Latil, M" uniqKey="Latil M" first="M." last="Latil">M. Latil</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Matot, B" sort="Matot, B" uniqKey="Matot B" first="B." last="Matot">B. Matot</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>NMR Laboratory, Institute of Myology</institution>, Paris 75013,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>CEA, I2BM, MIRCen, NMR Laboratory</institution>, Paris 75013,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Carlier, P G" sort="Carlier, P G" uniqKey="Carlier P" first="P. G." last="Carlier">P. G. Carlier</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>NMR Laboratory, Institute of Myology</institution>, Paris 75013,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>CEA, I2BM, MIRCen, NMR Laboratory</institution>, Paris 75013,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Latronico, N" sort="Latronico, N" uniqKey="Latronico N" first="N." last="Latronico">N. Latronico</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Anesthesia and Reanimation Department, Department of Surgery, University of Brescia</institution>, Brescia 25121,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huchet, C" sort="Huchet, C" uniqKey="Huchet C" first="C." last="Huchet">C. Huchet</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>INSERM UMR1087/ CNRS UMR6291, Institut du Thorax, Therassay, Université de Nantes, Faculté des Sciences et des Techniques</institution>, F44322 Nantes 44000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lafoux, A" sort="Lafoux, A" uniqKey="Lafoux A" first="A." last="Lafoux">A. Lafoux</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>INSERM UMR1087/ CNRS UMR6291, Institut du Thorax, Therassay, Université de Nantes, Faculté des Sciences et des Techniques</institution>, F44322 Nantes 44000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sharshar, T" sort="Sharshar, T" uniqKey="Sharshar T" first="T." last="Sharshar">T. Sharshar</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Service de réanimation médico-chirurgicale adulte, Hôpital Raymond Poincaré</institution>, Garches 92380,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Université Versailles Saint Quentin</institution>, Versailles 78000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>TRIGGERSEP, F-CRIN Network</institution>, Versailles 78000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ricchetti, M" sort="Ricchetti, M" uniqKey="Ricchetti M" first="M." last="Ricchetti">M. Ricchetti</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Developmental and Stem Cell Biology, Institut Pasteur, Stem Cells and Development</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Team Stability of Nuclear and Mitochondrial DNA, CNRS UMR 3525</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chretien, F" sort="Chretien, F" uniqKey="Chretien F" first="F." last="Chrétien">F. Chrétien</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Infection and Epidemiology Department, Institut Pasteur Human Histopathology and Animal Models Unit</institution>, 75724 cedex15, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>TRIGGERSEP, F-CRIN Network</institution>, Versailles 78000,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a11"><institution>Laboratoire de Neuropathologie, Centre Hospitalier Sainte Anne</institution>, Paris 75014,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a12"><institution>Paris Descartes University, Sorbonne Paris Cité</institution>, Paris 75006,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Sepsis, or systemic inflammatory response syndrome, is the major cause of critical illness resulting in admission to intensive care units. Sepsis is caused by severe infection and is associated with mortality in 60% of cases. Morbidity due to sepsis is complicated by neuromyopathy, and patients face long-term disability due to muscle weakness, energetic dysfunction, proteolysis and muscle wasting. These processes are triggered by pro-inflammatory cytokines and metabolic imbalances and are aggravated by malnutrition and drugs. Skeletal muscle regeneration depends on stem (satellite) cells. Herein we show that mitochondrial and metabolic alterations underlie the sepsis-induced long-term impairment of satellite cells and lead to inefficient muscle regeneration. Engrafting mesenchymal stem cells improves the septic status by decreasing cytokine levels, restoring mitochondrial and metabolic function in satellite cells, and improving muscle strength. These findings indicate that sepsis affects quiescent muscle stem cells and that mesenchymal stem cells might act as a preventive therapeutic approach for sepsis-related morbidity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cohen, J" uniqKey="Cohen J">J. Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gamrin, L" uniqKey="Gamrin L">L. Gamrin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mittendorfer, B" uniqKey="Mittendorfer B">B. Mittendorfer</name></author><author><name sortKey="Gore, D C" uniqKey="Gore D">D. C. Gore</name></author><author><name sortKey="Herndon, D N" uniqKey="Herndon D">D. N. Herndon</name></author><author><name sortKey="Wolfe, R R" uniqKey="Wolfe R">R. R. Wolfe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rennie, M J" uniqKey="Rennie M">M. J. Rennie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Windmueller, H G" uniqKey="Windmueller H">H. G. Windmueller</name></author><author><name sortKey="Spaeth, A E" uniqKey="Spaeth A">A. E. Spaeth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Newsholme, E A" uniqKey="Newsholme E">E. A. Newsholme</name></author><author><name sortKey="Parry Billings, M" uniqKey="Parry Billings M">M. Parry-Billings</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vary, T C" uniqKey="Vary T">T. C. Vary</name></author><author><name sortKey="Kimball, S R" uniqKey="Kimball S">S. R. Kimball</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langhans, C" uniqKey="Langhans C">C. Langhans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reid, W D" uniqKey="Reid W">W. D. Reid</name></author><author><name sortKey="Macgowan, N A" uniqKey="Macgowan N">N. A. MacGowan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonaldo, P" uniqKey="Bonaldo P">P. Bonaldo</name></author><author><name sortKey="Sandri, M" uniqKey="Sandri M">M. Sandri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wollersheim, T" uniqKey="Wollersheim T">T. Wollersheim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herridge, M S" uniqKey="Herridge M">M. S. Herridge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iwashyna, T J" uniqKey="Iwashyna T">T. J. Iwashyna</name></author><author><name sortKey="Ely, E W" uniqKey="Ely E">E. W. Ely</name></author><author><name sortKey="Smith, D M" uniqKey="Smith D">D. M. Smith</name></author><author><name sortKey="Langa, K M" uniqKey="Langa K">K. M. Langa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lepper, C" uniqKey="Lepper C">C. Lepper</name></author><author><name sortKey="Partridge, T A" uniqKey="Partridge T">T. A. Partridge</name></author><author><name sortKey="Fan, C M" uniqKey="Fan C">C. M. Fan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murphy, M M" uniqKey="Murphy M">M. M. Murphy</name></author><author><name sortKey="Lawson, J A" uniqKey="Lawson J">J. A. Lawson</name></author><author><name sortKey="Mathew, S J" uniqKey="Mathew S">S. J. Mathew</name></author><author><name sortKey="Hutcheson, D A" uniqKey="Hutcheson D">D. A. Hutcheson</name></author><author><name sortKey="Kardon, G" uniqKey="Kardon G">G. Kardon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sambasivan, R" uniqKey="Sambasivan R">R. Sambasivan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trachootham, D" uniqKey="Trachootham D">D. Trachootham</name></author><author><name sortKey="Lu, W" uniqKey="Lu W">W. Lu</name></author><author><name sortKey="Ogasawara, M A" uniqKey="Ogasawara M">M. A. Ogasawara</name></author><author><name sortKey="Nilsa, R D" uniqKey="Nilsa R">R. D. Nilsa</name></author><author><name sortKey="Huang, P" uniqKey="Huang P">P. Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sambasivan, R" uniqKey="Sambasivan R">R. Sambasivan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davis, R L" uniqKey="Davis R">R. L. Davis</name></author><author><name sortKey="Weintraub, H" uniqKey="Weintraub H">H. Weintraub</name></author><author><name sortKey="Lassar, A B" uniqKey="Lassar A">A. B. Lassar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lassar, A B" uniqKey="Lassar A">A. B. Lassar</name></author><author><name sortKey="Paterson, B M" uniqKey="Paterson B">B. M. Paterson</name></author><author><name sortKey="Weintraub, H" uniqKey="Weintraub H">H. Weintraub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andres, V" uniqKey="Andres V">V. Andres</name></author><author><name sortKey="Walsh, K" uniqKey="Walsh K">K. Walsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malec, V" uniqKey="Malec V">V. Malec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pamplona, R" uniqKey="Pamplona R">R. Pamplona</name></author><author><name sortKey="Costantini, D" uniqKey="Costantini D">D. Costantini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor Fishwick, D A" uniqKey="Taylor Fishwick D">D. A. Taylor-Fishwick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsang, C K" uniqKey="Tsang C">C. K. Tsang</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Thomas, J" uniqKey="Thomas J">J. Thomas</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Zheng, X F" uniqKey="Zheng X">X. F. Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doridot, L" uniqKey="Doridot L">L. Doridot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Handschin, C" uniqKey="Handschin C">C. Handschin</name></author><author><name sortKey="Spiegelman, B M" uniqKey="Spiegelman B">B. M. Spiegelman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chatre, L" uniqKey="Chatre L">L. Chatre</name></author><author><name sortKey="Ricchetti, M" uniqKey="Ricchetti M">M. Ricchetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Latil, M" uniqKey="Latil M">M. Latil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, X" uniqKey="Xu X">X. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matthay, M A" uniqKey="Matthay M">M. A. Matthay</name></author><author><name sortKey="Goolaerts, A" uniqKey="Goolaerts A">A. Goolaerts</name></author><author><name sortKey="Howard, J P" uniqKey="Howard J">J. P. Howard</name></author><author><name sortKey="Lee, J W" uniqKey="Lee J">J. W. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prockop, D J" uniqKey="Prockop D">D. J. Prockop</name></author><author><name sortKey="Kota, D J" uniqKey="Kota D">D. J. Kota</name></author><author><name sortKey="Bazhanov, N" uniqKey="Bazhanov N">N. Bazhanov</name></author><author><name sortKey="Reger, R L" uniqKey="Reger R">R. L. Reger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, D J" uniqKey="Weiss D">D. J. Weiss</name></author><author><name sortKey="Kolls, J K" uniqKey="Kolls J">J. K. Kolls</name></author><author><name sortKey="Ortiz, L A" uniqKey="Ortiz L">L. A. Ortiz</name></author><author><name sortKey="Panoskaltsis Mortari, A" uniqKey="Panoskaltsis Mortari A">A. Panoskaltsis-Mortari</name></author><author><name sortKey="Prockop, D J" uniqKey="Prockop D">D. J. Prockop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yagi, H" uniqKey="Yagi H">H. Yagi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Houlihan, D D" uniqKey="Houlihan D">D. D. Houlihan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hotchkiss, R S" uniqKey="Hotchkiss R">R. S. Hotchkiss</name></author><author><name sortKey="Nicholson, D W" uniqKey="Nicholson D">D. W. Nicholson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pittenger, M F" uniqKey="Pittenger M">M. F. Pittenger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wakitani, S" uniqKey="Wakitani S">S. Wakitani</name></author><author><name sortKey="Saito, T" uniqKey="Saito T">T. Saito</name></author><author><name sortKey="Caplan, A I" uniqKey="Caplan A">A. I. Caplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caplan, A I" uniqKey="Caplan A">A. I. Caplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kelly, R" uniqKey="Kelly R">R. Kelly</name></author><author><name sortKey="Alonso, S" uniqKey="Alonso S">S. Alonso</name></author><author><name sortKey="Tajbakhsh, S" uniqKey="Tajbakhsh S">S. Tajbakhsh</name></author><author><name sortKey="Cossu, G" uniqKey="Cossu G">G. Cossu</name></author><author><name sortKey="Buckingham, M" uniqKey="Buckingham M">M. Buckingham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huchet, C" uniqKey="Huchet C">C. Huchet</name></author><author><name sortKey="Leoty, C" uniqKey="Leoty C">C. Leoty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godt, R E" uniqKey="Godt R">R. E. Godt</name></author><author><name sortKey="Nosek, T M" uniqKey="Nosek T">T. M. Nosek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Jonghe, B" uniqKey="De Jonghe B">B. De Jonghe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Letter, M A" uniqKey="De Letter M">M. A. De Letter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fletcher, S N" uniqKey="Fletcher S">S. N. Fletcher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zifko, U A" uniqKey="Zifko U">U. A. Zifko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dos Santos, C C" uniqKey="Dos Santos C">C. C. dos Santos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, S R" uniqKey="Hall S">S. R. Hall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kusadasi, N" uniqKey="Kusadasi N">N. Kusadasi</name></author><author><name sortKey="Groeneveld, A B" uniqKey="Groeneveld A">A. B. Groeneveld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mei, S H" uniqKey="Mei S">S. H. Mei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nemeth, K" uniqKey="Nemeth K">K. Nemeth</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Italie</li></country></list><tree><country name="France"><noRegion><name sortKey="Rocheteau, P" sort="Rocheteau, P" uniqKey="Rocheteau P" first="P." last="Rocheteau">P. Rocheteau</name></noRegion><name sortKey="Bardon, J" sort="Bardon, J" uniqKey="Bardon J" first="J." last="Bardon">J. Bardon</name><name sortKey="Briand, D" sort="Briand, D" uniqKey="Briand D" first="D." last="Briand">D. Briand</name><name sortKey="Carlier, P G" sort="Carlier, P G" uniqKey="Carlier P" first="P. G." last="Carlier">P. G. Carlier</name><name sortKey="Carlier, P G" sort="Carlier, P G" uniqKey="Carlier P" first="P. G." last="Carlier">P. G. Carlier</name><name sortKey="Chatre, L" sort="Chatre, L" uniqKey="Chatre L" first="L." last="Chatre">L. Chatre</name><name sortKey="Chatre, L" sort="Chatre, L" uniqKey="Chatre L" first="L." last="Chatre">L. Chatre</name><name sortKey="Chretien, F" sort="Chretien, F" uniqKey="Chretien F" first="F." last="Chrétien">F. Chrétien</name><name sortKey="Chretien, F" sort="Chretien, F" uniqKey="Chretien F" first="F." last="Chrétien">F. Chrétien</name><name sortKey="Chretien, F" sort="Chretien, F" uniqKey="Chretien F" first="F." last="Chrétien">F. Chrétien</name><name sortKey="Chretien, F" sort="Chretien, F" uniqKey="Chretien F" first="F." last="Chrétien">F. Chrétien</name><name sortKey="Crochemore, C" sort="Crochemore, C" uniqKey="Crochemore C" first="C." last="Crochemore">C. Crochemore</name><name sortKey="Crochemore, C" sort="Crochemore, C" uniqKey="Crochemore C" first="C." last="Crochemore">C. Crochemore</name><name sortKey="Huchet, C" sort="Huchet, C" uniqKey="Huchet C" first="C." last="Huchet">C. Huchet</name><name sortKey="Jouvion, G" sort="Jouvion, G" uniqKey="Jouvion G" first="G." last="Jouvion">G. Jouvion</name><name sortKey="Lafoux, A" sort="Lafoux, A" uniqKey="Lafoux A" first="A." last="Lafoux">A. Lafoux</name><name sortKey="Latil, M" sort="Latil, M" uniqKey="Latil M" first="M." last="Latil">M. Latil</name><name sortKey="Lecci, P P" sort="Lecci, P P" uniqKey="Lecci P" first="P. P." last="Lecci">P. P. Lecci</name><name sortKey="Matot, B" sort="Matot, B" uniqKey="Matot B" first="B." last="Matot">B. Matot</name><name sortKey="Matot, B" sort="Matot, B" uniqKey="Matot B" first="B." last="Matot">B. Matot</name><name sortKey="Mebarki, M" sort="Mebarki, M" uniqKey="Mebarki M" first="M." last="Mebarki">M. Mebarki</name><name sortKey="Ricchetti, M" sort="Ricchetti, M" uniqKey="Ricchetti M" first="M." last="Ricchetti">M. Ricchetti</name><name sortKey="Ricchetti, M" sort="Ricchetti, M" uniqKey="Ricchetti M" first="M." last="Ricchetti">M. Ricchetti</name><name sortKey="Serrani, P" sort="Serrani, P" uniqKey="Serrani P" first="P." last="Serrani">P. Serrani</name><name sortKey="Sharshar, T" sort="Sharshar, T" uniqKey="Sharshar T" first="T." last="Sharshar">T. Sharshar</name><name sortKey="Sharshar, T" sort="Sharshar, T" uniqKey="Sharshar T" first="T." last="Sharshar">T. Sharshar</name><name sortKey="Sharshar, T" sort="Sharshar, T" uniqKey="Sharshar T" first="T." last="Sharshar">T. Sharshar</name><name sortKey="Sharshar, T" sort="Sharshar, T" uniqKey="Sharshar T" first="T." last="Sharshar">T. Sharshar</name></country><country name="Italie"><noRegion><name sortKey="Latronico, N" sort="Latronico, N" uniqKey="Latronico N" first="N." last="Latronico">N. Latronico</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Lorraine/explor/InforLorV4/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000744 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000744 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Lorraine
|area= InforLorV4
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4682118
|texte= Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26666572" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a InforLorV4
| This area was generated with Dilib version V0.6.33. |  |